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CasNo： 9003-39-8
Chemical Description polyvinylpyrrolidone
CAS NO. :9003-39-8
INCI Name:PVP
Chemical Name: Polyvinylpyrrolidone
Molecular Formula:(C6H9NO)n
Form:white to creamy white powder;
Sensitive : Hygroscopic
Stability: Stable. Incompatible with strong oxidizing agents. Light sensitive. Hygroscopic.
Polyvinylpyrrolidone Property:Readily soluble in water and a variety of organic solvent;
Melting point : ~165 °C (dec.)
Density : 1,69 g/cm3
Storage temp.: Store at RT.
Packing and Storage
| 1 carboard drum | 25kgs |
| Q'ty/20'FCL: | 9MT |
| Q'ty/40FCL: | 18MT |
Please stored in dry place in room temperature.
Specifications for PVP K15(pharm grade:USP/BP/EP) mark in Yellow:
|
Product |
Povidone K15 |
Povidone K17 |
Povidone K25 |
Povidone K30 |
Povidone K60 |
Povidone K90 |
|
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Appearance |
White or yellowish-white,hygroscopic powder or flakes |
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Solubility |
Freely soluble in water,in ethano(96%) and in methanol,very slightly soluble in acetone. |
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Appearance of Solution |
Clearly and not moren intensely coloured than reference solution B6,BY6 or R6 |
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Identifications |
Meet ID Tests |
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pH Value(5% in aqueous solution) |
3.0-5.0 |
3.0-5.0 |
3.0-5.0 |
3.0-5.0 |
4.0-7.0 |
4.0-7.0 |
|
|
Viscosity(Expressed as K Value) |
12.75-17.25 |
15.3-18.36 |
22.5-27.0 |
27.0-32.4 |
54.0-64.8 |
81.0-97.2 |
|
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Adehydes(Expressed as Acetaldehyde) |
500 ppm max. |
500 ppm max. | 500 ppm max. | 500 ppm max. | 500 ppm max. | 500 ppm max. | |
|
Peroxides(Expressed as H2O2) |
400ppm max. |
400 ppm max | 400 ppm max | 400 ppm max | 400 ppm max | 400 ppm max | |
|
Formic Acid |
0.5% max. |
0.5% max. | 0.5% max. | 0.5% max. | 0.5% max. | 0.5% max. | |
|
Hydrazine |
1ppm max. |
1ppm max. | 1ppm max. | 1ppm max. | 1ppm max. | 1ppm max. | |
|
N-Vinylpyrrolidone(Impurity A) |
USP27 |
1000 ppm max. |
1000 ppm max. | 1000 ppm max. | 1000 ppm max. | 1000 ppm max. | 1000 ppm max. |
|
Current USP/EP/BP |
10 ppm max. |
10 ppm max. | 10 ppm max. | 10 ppm max. | 10 ppm max. | 10 ppm max. | |
|
2-Pyrrolidone(Impurity B) |
3.0% max. |
3.0% max. | 3.0% max. | 3.0% max. | 3.0% max. | 3.0% max. | |
|
Heavy Metals(as Pb) |
10 ppm max. |
10 ppm max. | 10 ppm max. | 10 ppm max. | 10 ppm max. | 10 ppm max. | |
|
Water |
5.0% max. |
5.0% max. |
5.0% max. |
5.0% max. |
5.0% max. |
5.0% max. |
|
|
Sulphated Ash |
0.1% max. |
0.1% max. |
0.1% max. |
0.1% max. |
0.1% max. |
0.1% max. |
|
|
Nitrogen Content |
11.5-12.8% |
11.5-12.8% |
11.5-12.8% |
11.5-12.8% |
11.5-12.8% |
11.5-12.8% |
|
PVP K15 can dissolve in water and most organic solvents. For this reasons, PVP has been widely used in drug tablets, especially in foreign countries, the use of PVP for tablet adhesive. For example: compound sulfamethoxazole, aspirin, compound aspirin, acetaminophen, vitamin c, dipyridamole, dimethyl tetracycline, clonidine, benzenesulfonamide, compound analgesic, chewable tablets.
The raising of insoluble drugs’ solubility in the human body also relatively increases the drug bioavailability, such as the coprecipitation of phenytoin and PVP increases 1.55 times the bioavailability. After coprecipitation, the solubility of insoluble drugs increase with the number of PVP molecular weight and the dosage of PVP. When using the same dosage of PVP (mass), the drug solubility increased in the order of PVP k15> PVP k30> PVP k90, for the solubilization of PVPitself according to PVP k15> PVP k30> PVP k90 order change, PVP K15 is used more in general.
